Smudge Là Gì

Single smudge cell (arrow) on a peripheral smear from a 59-year-old man with chronic lymphocytic leukemia. Smudge cells typically contain chromatin, but no identifiable cytoplasmic components. P, platelet (100x, oil).

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ParameterProperties

White blood cell, lymphocyte	Smudge cell
Also known as	Basket cell
Definition	Remnants of fragile cells that are generated during preparation of peripheral smear. They lack any identifiable cytoplasmic membrane or nuclear structure. Xem thêm: Bộ 2 Tua Vít 6 Cạnh, Tua Vít 5 Cạnh, Tua Vít 6 Cạnh Bền Đẹp, Giá Sỉ, Với Nhiều Ưu Đãi They contain dense nuclear material and/or chromatin strands. Xem thêm: Level 5 - Plants Vs
Conditions associated with the cell type	Seen on routine blood smears of virtually all patients with chronic lymphocytic leukemia (CLL); may also occur in other lymphoproliferative disorders and viral infections such as infectious mononucleosis.
Mechanism of formation	Malignant or virally infected lymphocytes lymphocytes are more fragile than normal lymphocytes. These fragile lymphocytes rupture in the process of ex vivo smear preparation, forming smudge cells that consist largely of nuclear material.
Source/author	William Aird
Reviewed & edited by	Parul Bhargava
References	J Clin Oncol. 2009;27:1844Leuk Res. 2010;34:1680

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